myd88 inhibitor t6167923 (MedChemExpress)
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myd88 inhibitor t6167923
Myd88 Inhibitor T6167923, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/myd88+inhibitor/T6167923/pmc13216715-102-29-32
Average 94 stars, based on 12 article reviews
Myd88 Inhibitor T6167923, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/myd88+inhibitor/T6167923/pmc13216715-102-29-32
Average 94 stars, based on 12 article reviews
myd88 inhibitor t6167923 - by Bioz Stars,
2026-09
94/100 stars
Images
1) Product Images from "Trichinella spiralis HSP70 Mediates Mice Immune Responses via TLR2/MyD88/ERK Signaling Pathway"
Article Title: Trichinella spiralis HSP70 Mediates Mice Immune Responses via TLR2/MyD88/ERK Signaling Pathway
Journal: Transboundary and Emerging Diseases
doi: 10.1155/tbed/5533482
Figure Legend Snippet: Recombinant Ts‐HSP70 promotes the expression of TLR2 and MyD88. Mouse macrophages were stimulated with 5, 10, 20, or 40 μg/mL rTs‐HSP70 for 12 h. Following stimulation, total cellular RNA and protein were extracted and analyzed. A. The effect of rTs‐HSP70 on the transcription level of TLR2 and MyD88 in mouse macrophage cells. B. Western blot analysis of the TLR2 and MyD88 expression in mouse macrophage cells after rTs‐HSP70 stimulation. Statistical differences among groups were determined by one‐way ANOVA followed by Duncan’s multiple range test. Different letters above the bars denote statistically significant differences ( p < 0.05), while the same letters indicate no significant difference.
Techniques Used: Recombinant, Expressing, Western Blot
Figure Legend Snippet: Recombinant Ts‐HSP70 affects mouse macrophage immune function via the TLR2/MyD88/ERK signaling pathway. Mouse macrophages were pretreated with a TLR2‐specific antibody (or control IgG) for 1 h, then stimulated with rTs‐HSP70 (1 μg/mL, 15 min) and harvested for Western blot. In the MyD88 inhibition assay, RAW264.7 cells were pretreated with the MyD88 inhibitor T6167923 (5, 10 μg/mL; DMSO control) for 18 h, then stimulated with rTs‐HSP70 (1 μg/mL, 15 min), and harvested for Western blot analysis. A. TLR2 blocking assay. B. MyD88 inhibition assay. Statistical differences among groups were determined by one‐way ANOVA followed by Duncan’s multiple range test. Different letters above bars indicate significant differences ( p < 0.05); the same letter indicates no significant difference.
Techniques Used: Recombinant, Control, Western Blot, Inhibition, Blocking Assay
Related Articles
Cell Culture:Article Title: Free heme induces neuroinflammation and cognitive impairment by microglial activation via the TLR4/MyD88/NF-κB signaling pathway. Article Snippet: On the first day, BV2 cells were maintained in Dulbecco’s modified Eagle’s medium (DMEM) (Gibco) supplemented with 10% fetal bovine serum (FBS) (Sigma–Aldrich, MO, USA) and 1% penicillin/ streptomycin (Gibco) in humidified 5% CO2 air environment at 37 °C. .. On the second day, the BV2 cell culture medium was replaced, and the cells were divided into 4 groups: 1) the Control group (BV2), in which BV2 cells were incubated with medium only for 24 h; 2) the Heme group (BV2 + Heme) in which BV2 cells were treated with 40 μM hemin (H9039, Sigma, USA) for 24 h; 3) the MyD88 inhibition group (BV2 + Heme + T6167923) in which BV2 cells were treated with 40 μM hemin and 2 μM Control:Article Title: Free heme induces neuroinflammation and cognitive impairment by microglial activation via the TLR4/MyD88/NF-κB signaling pathway. Article Snippet: On the first day, BV2 cells were maintained in Dulbecco’s modified Eagle’s medium (DMEM) (Gibco) supplemented with 10% fetal bovine serum (FBS) (Sigma–Aldrich, MO, USA) and 1% penicillin/ streptomycin (Gibco) in humidified 5% CO2 air environment at 37 °C. .. On the second day, the BV2 cell culture medium was replaced, and the cells were divided into 4 groups: 1) the Control group (BV2), in which BV2 cells were incubated with medium only for 24 h; 2) the Heme group (BV2 + Heme) in which BV2 cells were treated with 40 μM hemin (H9039, Sigma, USA) for 24 h; 3) the MyD88 inhibition group (BV2 + Heme + T6167923) in which BV2 cells were treated with 40 μM hemin and 2 μM Article Title: TXM-CB13 Improves the Intestinal Mucosal Barrier and Alleviates Colitis by Inhibiting the ROS/TXNIP/TRX/NLRP3 and TLR4/MyD88/NF-κB/NLRP3 Pathways Article Snippet: .. The cells were divided into the control, LPS, LPS + CB13 and LPS + MyD88 inhibitor + CB13 groups, and the Article Title: TXM-CB13 Improves the Intestinal Mucosal Barrier and Alleviates Colitis by Inhibiting the ROS/TXNIP/TRX/NLRP3 and TLR4/MyD88/NF-κB/NLRP3 Pathways. Article Snippet: .. The cells were divided into the control, LPS, LPS + CB13 and LPS + MyD88 inhibitor + CB13 groups, and the Incubation:Article Title: Free heme induces neuroinflammation and cognitive impairment by microglial activation via the TLR4/MyD88/NF-κB signaling pathway. Article Snippet: On the first day, BV2 cells were maintained in Dulbecco’s modified Eagle’s medium (DMEM) (Gibco) supplemented with 10% fetal bovine serum (FBS) (Sigma–Aldrich, MO, USA) and 1% penicillin/ streptomycin (Gibco) in humidified 5% CO2 air environment at 37 °C. .. On the second day, the BV2 cell culture medium was replaced, and the cells were divided into 4 groups: 1) the Control group (BV2), in which BV2 cells were incubated with medium only for 24 h; 2) the Heme group (BV2 + Heme) in which BV2 cells were treated with 40 μM hemin (H9039, Sigma, USA) for 24 h; 3) the MyD88 inhibition group (BV2 + Heme + T6167923) in which BV2 cells were treated with 40 μM hemin and 2 μM Article Title: Teleost-specific TLR23 in Takifugu rubripes recruits MyD88 to trigger ERK pathway and promotes antibacterial defense. Article Snippet: Takifugu rubripes is a highly valued cultured fish in Asia, while pathogen infections can result in severe diseases and lead to substantial economic losses.. Toll-like receptors (TLRs), as pattern recognition receptors, play a crucial role on recognition pathogens and initiation innate immune response.. However, the immunological properties of teleost-specific TLR23 remain largely unknown. Inhibition:Article Title: Free heme induces neuroinflammation and cognitive impairment by microglial activation via the TLR4/MyD88/NF-κB signaling pathway. Article Snippet: On the first day, BV2 cells were maintained in Dulbecco’s modified Eagle’s medium (DMEM) (Gibco) supplemented with 10% fetal bovine serum (FBS) (Sigma–Aldrich, MO, USA) and 1% penicillin/ streptomycin (Gibco) in humidified 5% CO2 air environment at 37 °C. .. On the second day, the BV2 cell culture medium was replaced, and the cells were divided into 4 groups: 1) the Control group (BV2), in which BV2 cells were incubated with medium only for 24 h; 2) the Heme group (BV2 + Heme) in which BV2 cells were treated with 40 μM hemin (H9039, Sigma, USA) for 24 h; 3) the MyD88 inhibition group (BV2 + Heme + T6167923) in which BV2 cells were treated with 40 μM hemin and 2 μM Activation Assay:Article Title: Teleost-specific TLR23 in Takifugu rubripes recruits MyD88 to trigger ERK pathway and promotes antibacterial defense. Article Snippet: Takifugu rubripes is a highly valued cultured fish in Asia, while pathogen infections can result in severe diseases and lead to substantial economic losses.. Toll-like receptors (TLRs), as pattern recognition receptors, play a crucial role on recognition pathogens and initiation innate immune response.. However, the immunological properties of teleost-specific TLR23 remain largely unknown. Western Blot:Article Title: Teleost-specific TLR23 in Takifugu rubripes recruits MyD88 to trigger ERK pathway and promotes antibacterial defense. Article Snippet: Takifugu rubripes is a highly valued cultured fish in Asia, while pathogen infections can result in severe diseases and lead to substantial economic losses.. Toll-like receptors (TLRs), as pattern recognition receptors, play a crucial role on recognition pathogens and initiation innate immune response.. However, the immunological properties of teleost-specific TLR23 remain largely unknown. |
